High-flow nasal cannula (HFNC) therapy is a non-invasive ventilatory support that has gained interest over the decade as a valid alternative to nasal continuous positive airway pressure (nCPAP) in children with respiratory failure. Its safety, availability, tolerability, and easy application have resulted its increasing usage, either in PICU or outside intensive care units. Despite its wide use in daily clinical practice, there is still a lack of guidelines to standardise the use of HFNC. In this talk , we will look at the current knowledge about the mechanisms of action, safety, clinical effects, and tolerance of HFNC in children, and review clinical practices algorithm for children with respiratory failure.